Behind the Haze Campaign: “The Great Manipulator.” This new licensable Message Package explains that vaping nicotine can put teens’ mental health at risk. “The Great Manipulator” shows teens how the nicotine in vapes can mess with, or “manipulate,” important neurotransmitters in their brains, triggering changes that have been linked to depression and anxiety. For example, nicotine can interfere with acetylcholine, which is connected to the way we experience emotions.